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Objective To detect the spreading scope of rectal cancer to mesorectum by RT PCR using carcinoembryonic antigen (CEA) mRNA as a marker and to investigate the excision scope of mesorectum in resection of rectal cancer. Methods Forty specimens from 40 rectal cancer patients who underwent curative operation was employed to detect the metastatic deposits scattered in the mesorectum by RT PCR using CEA as a marker. Results Nine of 40 (22.5%) specimens contained metastatic deposits scattered in the mesorectum. The metastasis was just within the range of 4cm mesorectum under the verge of tumor. The tumor spreading to mesorectum is correlated with Dukes stages,the infiltrated depth of bowel wall, tumor differentiation and tumor type( P 0.05). Conclusion The excision of mesorectum should be within the range of 5cm under the verge of tumor in surgical management of rectal cancer.
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Objective To comprehand and grasp epidemical distribution characteristics of colorectal cancer cases. WT5”HZMethods Between 1975 and 1999, 1 145 cases of colorectal carcinoma who had undergone a surgery in Nanfang Hospital were retrospectively studied and a survey of clinical epidemical distribution characteristics was made. ResultsWT5”BZ ①Though more elder cases were found in recent years, young patients still made up a high proportion(19%) of the cases.②The occurrence of mucoid and signet-ring cell carcinoma in young cases was higher than that in the elders( P 0 05). KG2Conclusion The study of clinical epidemiology provided dependabal bases for prevention and therapy of colorectal carcinoma.
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Objective To summarize the experience in diagnosis and treatment of rectal injury. Methods The diagnosis and treatment of 40 cases of rectal injury in the recent 6 years were retrospectively analysed. The diagnosis of rectal injury relied on injury history, clinical presentation,anorectal examination , sigmoid coloscopy ,and explorare laparotomy.38 cases treated by surgery ,including rectal repear ,sigmoid colostomy plus drainge ,and resection of injuried segment of rectum.1case treated by non-operation. 1 case died 2h after admittion. Results 39 cases recovered and 1 case died.Conclusions The condition of rectal injury is very complicate.Due attention should be paid to the diagnosis and treatment.
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Objective To investigate the clinical manifestations, histopathological patterns, and methods of diagnosis and treatment of primary malignant duodenal tumors. Methods The data of 82 patients with primary malignant duodenal tumors confirmed by pathology and admitted to our hospital over a 10-year period were analyzed retrospectively. Results Tumor location:Tumors were located in the peripapilla region in 64 cases, at the descending portion of the duodenum in 11 cases, at other regions of the duodenum in 7 cases. The common presenting symptoms and signs were abdominal pain in 57 cases, jaundice 53 cases, and gastrointestinal bleeding in 41 cases. In these patients, radical resection of tumor was performed in 36 cases, palliative resection of tumor in 31cases,and operative intervention was not done in 15 cases.The 5-year survival rate of followed-up patients in this group was 2.4%. Conclusions The common presenting symptoms and signs of patients with primary malignant duodenal tumors were abdominal pain, jaundice and GI bleeding, but these patients usually lack specific symptoms and signs. The chief pathologic type is adenocarcinoma and the predisposed site of occurrence is the duodenal papillary region and the descending duodenum . CT, B ultrasonography and gastroduodenoscopy are the chief measures for the diagnosis of primary duodenal malignant tumors, and surgical resection is the main modality of treatment of this disease. The prognosis of primary duodenal malignant tumors is very poor.
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Objective To study the relationship between anatomic site distribution and clinical pathologic characteristics of colorectal cancer(CRC). Methods Clinical data were collected from 790 patients in Nanfang Hospital admitted from 1990 to 1999. Results Mucous adenocarcinoma accounted for 26 5% in proximal colon, 10 1% in distal colon and 9 4% in rectum; Poor differentiation cancer accounted for 14 5%,5 7% and 10 0% respectively, and 85 3%,75 3% and 77 1% was in advanced stage of cancer (Dukes B, C and D) in proximal, distal colon and rectum respectively. There was significant difference( P 0 05) in pathologic type and tumor′s stage. Conclusions Proximal colon cancer has some significantly different characteristics from distal colon or rectal cancer, with more mucous adenocarcinoma, poor differentiation and later tumor stage.
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0.05), 9.6% vs. 17.0% were stage Ⅳ ( P